The effect of endotoxin adsorber haemoperfusion on microcirculation in septic pigs
نویسندگان
چکیده
Introduction Microcirculatory dysfunction plays an important role in sepsis-related multiple organ dysfunction.(1) Several studies has shown polymyxin B hemoperfusion has favorable effects on mean arterial pressure, vasopressor use, and mortality.(2) One rat sepsis study had found that microcirculation was better maintained in the polymyxin B hemoperfusion group.(3) However, the effects of polymyxin B hemoperfusion on the microcirculation of the intestinal mucosa, intestinal muscular-serosal layer, kidney, and liver were unknown. We used a fecal peritonitis-induced septic pig model to investigate the effect of polymyxin B perfusion on the microcirculation.
منابع مشابه
The effect of endotoxin adsorber hemoperfusion on microcirculation in patients with severe sepsis and septic shock
Introduction Microcirculatory dysfunction may result in multiple organ dysfunction during severe sepsis and septic shock. (1) A meta-analysis of randomized trials showed that polymyxin B hemoperfusion (PMX-HP), plasma exchange, and hemofiltration were associated with lower mortality. (2) Mesenteric microcirculation was better maintained with polymyxin B hemoperfusion in one rat sepsis study. (3...
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